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KMID : 0921620200500030195
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Journal of Bacteriology and Virology
2020 Volume.50 No. 3 p.195 ~ p.202
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In Vitro Virucidal Effect of Povidone-Iodine Against SARS-CoV-2
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Shin Kyeong-Ryeol
Kwak Kyung-Hee
Cui Chunguang
Bae Joon-Yong
Hong Woo-Sung
Park Man-Seong
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Abstract
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As of September 2020, SARS-CoV-2 has infected over 30 million people worldwide, and the death toll has now risen to 950,000. Given that Povidone-iodine (PVP-I) had consistently been showing the virucidal efficacy against various types of viruses, such as SARS-CoV, MERS-CoV, and Ebola, we conducted this study to figure out the virucidal effect against SARS-CoV-2 by using a viral plaque assay. We performed Kill-Time assays to assess the viral inactivation of SARS-CoV-2contaminants after the application of the PVP-I product (Betadine® Throat Spray, PVP-I 0.45%). This test consisted of clean and dirty conditions and was designed to check the viral titers at a contact time of 60 seconds, which were evaluated by plaque-reduction rates in Vero cells. This PVP-I product fully achieved ≥4 log 10reductions in viral titers under both clean and dirty conditions. This level of reduction, ≥4 log 10 (99.99%), in viral titers presented to be effective in terms of virucidal efficacy, according to the European standards, EN14476. This study revealed the virucidal efficacy of Betadine® Throat Spray against SARS-CoV-2 virus. Given that the convenience and availability of this product, we think that it may contribute to inhibit viral infection and transmissibility as an active type of personal protective equipment (PPE) by managing the hygiene of patients and medical professionals.
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KEYWORD
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COVID-19, SARS-CoV-2, Plaque, Povidone-iodine, Virucidal effect
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